← Back to all signals
RESEARCH PAPER ANALYSIS

Does HLA-DQA1*05 carriage have a greater impact on the outcome of infliximab therapy for isolated small-bowel Crohn's disease?

AI interpretation is pending for this paper.

Open original publication →
PMID39387318
JournalInternational journal of immunogenetics
Publication Date2024-10-10
Ingested2026-08-02 12:02 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Carriage of HLA-DQA1*05 is thought to increase the formation of anti-tumour necrosis factor alpha (TNF-α) antibodies, reducing the drug efficacy in Crohn's disease (CD) patients. However, little data are currently available for small-bowel Crohn's disease (SB-CD). A specific assessment of the impact of HLA-DQA1*05 on the clinical response to treatment with infliximab (IFX), a TNF-α antagonists, in SB-CD patients is necessary. We conducted a single-center retrospective study that included 106 SB-CD patients treated with IFX. The serum samples were collected for antibodies to infliximab (ATI) testing and HLA-DQA1*05 genotyping. Double-balloon enteroscopy (DBE) was performed following the IFX treatment, with endoscopic outcomes evaluated using the partial simple endoscopic score for CD (pSES-CD), whereas the clinical response was assessed with the Crohn's disease activity index (CDAI). Multivariate logistic regression and multivariate COX regression analyses were employed to analyze the correlation of the HLA-DQA1*05 genotypes with other clinical variables. In this study, 30.2% of SB-CD patients carried the HLA-DQA1*05 allele, which significantly increased their risk of ATI generation (odds ratio [OR] = 2.337, p = .043), but it was not associated with the clinical response to IFX and drug persistence (OR = 2.356, p = .145; OR = 0.457, p = .249). The endoscopic remission rates were 40.6% (13/32) and 55.4% (41/74) in HLA-DQA1*05 carriers and non-carriers, respectively. HLA-DQA1*05 was not associated with endoscopic remission (OR = 0.684, p = .414). The HLA-DQA1*05 variant is identified as a significant risk factor of ATI formation in Chinese patients with SB-CD, but is not associated with the clinical response of IFX treatment and endoscopic remission of SB lesions.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 [Surgical treatment of anterior visual pathway gliomas in children using intraoperative neurophysiological monitoring and MR tractography]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 59.24 2 [Desmoplastic infantile gangliogliomas/astrocytomas: clinical course, surgery and morphological diagnosis]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 57.5 3 Donor-source-specific competing risks of relapse and non-relapse mortality in adult B-ALL allogeneic hematopoietic stem cell transplantation on a rabbit antithymocyte globulin-based platform. Annals of hematology 69.12 4 Thoracic Pathologies Requiring Surgical or Interventional Management in Solid-Organ Transplant Recipients. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 69.1 5 Erythema Multiforme after Liver Transplant: A Rare Pediatric Case Report. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 52.3 6 Population-Level Associations of Diabetes Prevalence and Childhood Overweight with Kidney Cancer Mortality in Türkiye. Journal of clinical medicine 37.0 7 A Mechanistic Map of the Phenotypic Complexity in Recessive Dystrophic Epidermolysis Bullosa Provides Basis for Therapeutic Target Discovery and Drug Repurposing. International journal of molecular sciences 62.4 8 AAV9 Gene Therapy for Ovarian Dysfunction and Reproductive Aging: Molecular Mechanisms, Therapeutic Targets, and Translational Perspectives. International journal of molecular sciences 52.21 9 Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy. Journal of clinical medicine 63.84 10 Digital 3D Technology in Pediatric Surgical Oncology: An Expert White Paper. Cancers 58.4 11 Maternal Gestational Hypertension Is Associated with Reduced TSG-6 in Human Milk: Potential Implications for Neonatal Immunological Support. International journal of molecular sciences 52.4 12 Enrichment-Free Rare Cell Profiling in Pediatric Osteosarcoma Reveals a Circulating Cell Population Associated with Relapse-Free Survival. Cancers 63.74 13 Treatment Outcomes and Prognostic Factors in Children with Myeloid Leukemia Associated with Down Syndrome: A Nationwide Polish Retrospective Study. Journal of clinical medicine 65.94 14 Unveiling the Role of [18F]FDG PET/CT in NUT Carcinoma: Insights from a Case Series and Literature Review. Diagnostics (Basel, Switzerland) 60.7 15 Development and Initial Validation of High-Fidelity 3D Hybrid Simulators for Training in Complex Pediatric Oncologic Surgery. Cancers 59.5 16 H3K27M Mutation Modulates the Antigenic Landscape in Diffuse Midline Glioma. Cancers 60.0 17 Advanced Drug Delivery in Pediatric Neurology: Developmental Barriers, Nanocarrier Strategies, and Translational Challenges. International journal of molecular sciences 66.36 18 Occurrence and Severity of Mental Health Disorders Among Patients Treated for Malignant Neoplasms: A Narrative Review with Preliminary Quantitative Synthesis. Journal of clinical medicine 75.4 19 Occult Neoplasms in Sudden Unexpected Death in Infancy: A Scoping Review of Post-Mortem Findings. Diagnostics (Basel, Switzerland) 58.5 20 Clinical Predictors of Surgical Intervention and Ovarian Torsion in Adolescents With Ovarian Cystic Lesions. The journal of obstetrics and gynaecology research 69.7 21 Clinical and Genetic Characterization of Russian Patients with von Hippel-Lindau Syndrome. International journal of molecular sciences 57.5 22 Nursing Perspectives on Palliative and Supportive Care in Paediatric Oncology: A Multicentre Qualitative Study. Nursing open 59.9 23 Astrovirus Gastroenteritis Mimicking Necrotizing Enterocolitis in a Pediatric Liver Transplant Recipient: A Case Report and Successful Conservative Management. Pediatric transplantation 54.3 24 Understanding vaccination against human papillomavirus (HPV): knowledge and perceptions among parents or guardians and healthcare workers, Germany, 2023. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 59.2 25 Developing a Dual-Targeting CD33/CD70 CAR T-Cell Strategy Against Acute Myeloid Leukemia to Overcome Tumor Heterogeneity. Cancers 58.5 26 Minor Myeloid Leukemic Populations in Pediatric Acute Lymphoblastic Leukemia: A Potentially Underrecognized Mixed-Phenotype Tumor? International journal of molecular sciences 65.4 27 A Rare Case of Benign-Appearing Myoepithelial Carcinoma of the Hard Palate in an Adolescent. Journal of clinical medicine 56.0 28 18β-Glycyrrhetinic Acid Exerts Subgroup-Specific Antitumor Activity and Enhances Radiosensitivity in Medulloblastoma. Cancers 60.4 29 The Osteosarcoma Tumor Microenvironment: Supportive of Tumor Progression, Hostile to Immunity, but Therapeutically Targetable. Cancers 71.14 30 Radiation-Induced Contrast Enhancement After Proton Therapy for Paediatric Brain Tumours: Association with Variable Relative Biological Effectiveness and Linear Energy Transfer. Cancers 66.14 31 Development and temporal validation of an interpretable prediction model for 30-day meningitis or ventriculitis after pediatric brain tumor surgery: An 895-patient cohort study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 63.5 32 Megakaryopoiesis and its dysregulation in paediatric acute megakaryoblastic leukaemia. Leukemia research 62.4
PATIENT-FRIENDLY SUMMARY

Does HLA-DQA1*05 carriage have a greater impact on the outcome of infliximab therapy for isolated small-bowel Crohn's disease?

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic