← Back to all signals
RESEARCH PAPER ANALYSIS

Features and prognostic significance of soluble TIM-3 and its ligands Gal-9 and CEACAM1 levels in the diagnostic bone marrow of adult acute myeloid leukemia patients.

AI interpretation is pending for this paper.

Open original publication →
PMID39267264
JournalJournal of leukocyte biology
Publication Date2024-12-31
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

The prognostic significance of soluble immune checkpoint molecule TIM-3 and its ligands in the plasma has been illustrated in various solid tumors, but such study in newly diagnosed acute myeloid leukemia (AML) remains absent. Soluble TIM-3, Gal-9, and CEACAM1 levels in bone marrow plasma samples collected from 90 adult AML patients at diagnosis and 12 healthy donors were measured by enzyme-linked immunosorbent assays, and 16 AML patients were simultaneously tested cell membrane TIM-3 expression by multicolor flow cytometry. AML patients had significantly elevated soluble TIM-3 levels and similar soluble Gal-9 and CEACAM1 levels compared with healthy donors (P = 0.0003, 0.26, and 0.96, respectively). In the whole cohort, a high soluble TIM-3 level was the sole independent adverse prognostic factor for relapse-free survival (RFS) (P = 0.0060), and together with adverse European LeukemiaNet genetic risk they were independent poor prognostic factors for event-free survival (P = 0.0030 and 0.0040, respectively). A high soluble CEACAM1 level was significantly related to lower RFS (P = 0.028). In addition, a high soluble Gal-9 level had a significant association with lower RFS in patients receiving allogeneic hematopoietic stem cell transplantation at the first complete remission (P = 0.037). Furthermore, soluble TIM-3 level tended to have positive correlation with the percentage of nonblast myeloid TIM-3+ cells in nucleated cells in AML (r = 0.48, P = 0.073). Therefore, the high soluble TIM-3 level in the diagnostic BM plasma predicted poor outcome in adult AML patients, and a high sGal-9 level was associated with relapse after allogeneic hematopoietic stem cell transplantation.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 [Surgical treatment of anterior visual pathway gliomas in children using intraoperative neurophysiological monitoring and MR tractography]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 59.24 2 [Desmoplastic infantile gangliogliomas/astrocytomas: clinical course, surgery and morphological diagnosis]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 57.5 3 Donor-source-specific competing risks of relapse and non-relapse mortality in adult B-ALL allogeneic hematopoietic stem cell transplantation on a rabbit antithymocyte globulin-based platform. Annals of hematology 69.12 4 Thoracic Pathologies Requiring Surgical or Interventional Management in Solid-Organ Transplant Recipients. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 69.1 5 Erythema Multiforme after Liver Transplant: A Rare Pediatric Case Report. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 52.3 6 Population-Level Associations of Diabetes Prevalence and Childhood Overweight with Kidney Cancer Mortality in Türkiye. Journal of clinical medicine 37.0 7 A Mechanistic Map of the Phenotypic Complexity in Recessive Dystrophic Epidermolysis Bullosa Provides Basis for Therapeutic Target Discovery and Drug Repurposing. International journal of molecular sciences 62.4 8 AAV9 Gene Therapy for Ovarian Dysfunction and Reproductive Aging: Molecular Mechanisms, Therapeutic Targets, and Translational Perspectives. International journal of molecular sciences 52.21 9 Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy. Journal of clinical medicine 63.84 10 Digital 3D Technology in Pediatric Surgical Oncology: An Expert White Paper. Cancers 58.4 11 Maternal Gestational Hypertension Is Associated with Reduced TSG-6 in Human Milk: Potential Implications for Neonatal Immunological Support. International journal of molecular sciences 52.4 12 Enrichment-Free Rare Cell Profiling in Pediatric Osteosarcoma Reveals a Circulating Cell Population Associated with Relapse-Free Survival. Cancers 63.74 13 Treatment Outcomes and Prognostic Factors in Children with Myeloid Leukemia Associated with Down Syndrome: A Nationwide Polish Retrospective Study. Journal of clinical medicine 65.94 14 Unveiling the Role of [18F]FDG PET/CT in NUT Carcinoma: Insights from a Case Series and Literature Review. Diagnostics (Basel, Switzerland) 60.7 15 Development and Initial Validation of High-Fidelity 3D Hybrid Simulators for Training in Complex Pediatric Oncologic Surgery. Cancers 59.5 16 H3K27M Mutation Modulates the Antigenic Landscape in Diffuse Midline Glioma. Cancers 60.0 17 Advanced Drug Delivery in Pediatric Neurology: Developmental Barriers, Nanocarrier Strategies, and Translational Challenges. International journal of molecular sciences 66.36 18 Occurrence and Severity of Mental Health Disorders Among Patients Treated for Malignant Neoplasms: A Narrative Review with Preliminary Quantitative Synthesis. Journal of clinical medicine 75.4 19 Occult Neoplasms in Sudden Unexpected Death in Infancy: A Scoping Review of Post-Mortem Findings. Diagnostics (Basel, Switzerland) 58.5 20 Clinical Predictors of Surgical Intervention and Ovarian Torsion in Adolescents With Ovarian Cystic Lesions. The journal of obstetrics and gynaecology research 69.7 21 Clinical and Genetic Characterization of Russian Patients with von Hippel-Lindau Syndrome. International journal of molecular sciences 57.5 22 Nursing Perspectives on Palliative and Supportive Care in Paediatric Oncology: A Multicentre Qualitative Study. Nursing open 59.9 23 Astrovirus Gastroenteritis Mimicking Necrotizing Enterocolitis in a Pediatric Liver Transplant Recipient: A Case Report and Successful Conservative Management. Pediatric transplantation 54.3 24 Understanding vaccination against human papillomavirus (HPV): knowledge and perceptions among parents or guardians and healthcare workers, Germany, 2023. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 59.2 25 Developing a Dual-Targeting CD33/CD70 CAR T-Cell Strategy Against Acute Myeloid Leukemia to Overcome Tumor Heterogeneity. Cancers 58.5 26 Minor Myeloid Leukemic Populations in Pediatric Acute Lymphoblastic Leukemia: A Potentially Underrecognized Mixed-Phenotype Tumor? International journal of molecular sciences 65.4 27 A Rare Case of Benign-Appearing Myoepithelial Carcinoma of the Hard Palate in an Adolescent. Journal of clinical medicine 56.0 28 18β-Glycyrrhetinic Acid Exerts Subgroup-Specific Antitumor Activity and Enhances Radiosensitivity in Medulloblastoma. Cancers 60.4 29 The Osteosarcoma Tumor Microenvironment: Supportive of Tumor Progression, Hostile to Immunity, but Therapeutically Targetable. Cancers 71.14 30 Radiation-Induced Contrast Enhancement After Proton Therapy for Paediatric Brain Tumours: Association with Variable Relative Biological Effectiveness and Linear Energy Transfer. Cancers 66.14 31 Development and temporal validation of an interpretable prediction model for 30-day meningitis or ventriculitis after pediatric brain tumor surgery: An 895-patient cohort study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 63.5 32 Megakaryopoiesis and its dysregulation in paediatric acute megakaryoblastic leukaemia. Leukemia research 62.4
PATIENT-FRIENDLY SUMMARY

Features and prognostic significance of soluble TIM-3 and its ligands Gal-9 and CEACAM1 levels in the diagnostic bone marrow of adult acute myeloid leukemia patients.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic