← Back to all signals
RESEARCH PAPER ANALYSIS

Targeting histone deacetylase 1 (HDAC1) in the bone marrow stromal cells revers imatinib resistance by modulating IL-6 in Ph + acute lymphoblastic leukemia.

AI interpretation is pending for this paper.

Open original publication →
PMID38847852
JournalAnnals of hematology
Publication Date2024-06-07
Ingested2026-08-02 12:02 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Bone marrow stromal cells (BMSCs) can promote the growth of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Histone deacetylases (HDACs) play essential roles in the proliferation and apoptosis resistance of Ph + ALL cells. In our previous study, inhibiting histone deacetylase 1 (HDAC1) decreases the proliferation of Ph + ALL cells. However, little is known regarding how HDAC1 in BMSCs of Ph + ALL patients affects the imatinib (IM) resistance. Therefore, the present work examined the roles of HDAC1 in BMSCs. Overexpression of HDAC1 was found in BMSCs of Ph + ALL patients with IM resistance. In addition, the Ph + ALL cell line SUP-B15 was co-cultured with BMSCs after lentivirus transfection for regulating HDAC1 expression. Knockdown of HDAC1 within BMSCs elevated the IM-mediated SUP-B15 cell apoptosis, while increasing HDAC1 expression had an opposite effect. IL-6 in BMSCs, which is an important factor for the microenvironment-associated chemoresistance, showed evident up-regulation in HDAC1-upregulated BMSCs and down-regulation in HDAC1-downregulated BMSCs. While recombinant IL-6 (rIL-6) can reversed the sensitivity of SUP-B15 cells to IM induced by downregulating HDAC1 expression in BMSCs. HDAC1 showed positive regulation on IL-6 transcription and secretion. Moreover, IL-6 secretion induced by HDAC1 in BMSCs might enhance IM resistance in Ph + ALL cells. With regard to the underlying molecular mechanism, NF-κB, an important signal responsible for IL-6 transcription in BMSCs, mediated the HDAC1-regulated IL-6 expression. Collectively, this study facilitated to develop HDAC1 inhibitors based not only the corresponding direct anti-Ph + ALL activity but also the regulation of bone marrow microenvironment.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 18F-FDG PET/CT-based Metabolic-clinical prognostic model could refine risk stratification in high-risk neuroblastoma. BMC medical imaging 81.2 2 Tuberous sclerosis with renal leiomyoma: a case report. BMC urology 45.5 3 Advances in CBFA2T3::GLIS2 fusion gene in pediatric acute myeloid leukemia: from molecular mechanisms to targeted therapeutic strategies. Annals of hematology 64.19 4 Delayed diagnosis of tuberous sclerosis complex in a young adult with long-term refractory epilepsy: a case report. Journal of medical case reports 59.02 5 Neonatal Immature Retroperitoneal Teratoma With Pancreatic Involvement and Intraoperative Findings Mimicking Fetus in Fetu. Cureus 58.4 6 Pediatric Orbital Langerhans Cell Histiocytosis With Dural Adherence Requiring Orbital Roof Reconstruction: A Case Report. Cureus 51.9 7 Pregnancy-Associated Torsion of an Ovarian Dermoid Cyst: A Case Report. Cureus 48.7 8 Templated lymph node sampling during surgery for pediatric renal tumors increases lymph node yield and does not increase long-term postoperative complication rates. Journal of pediatric urology 61.9 9 Radiographic progression patterns and treatment response in adult H3 K27-altered diffuse midline glioma: a descriptive review and single center case series. Frontiers in oncology 62.96 10 A study protocol for rural tribal school partnerships for the primary prevention of obesity among American Indian youth (P2). Frontiers in public health 73.0 11 Clinical features of ROHHAD syndrome and treatment outcomes following rituximab therapy: a descriptive case series of Chinese children. Frontiers in pediatrics 67.38 12 Safety and efficacy of intrathecal methotrexate in severe anti-NMDAR encephalitis: a single-institution retrospective study. Frontiers in immunology 74.4 13 Case Report: When obstructive sleep apnea is not benign-nasopharyngeal rhabdomyosarcoma in a 3-year-old. Frontiers in pediatrics 63.9 14 CD44 Predisposes the Epileptogenesis of Cortical Tubers by Regulating CASK and Acts as a Potential Biomarker to Identify Epileptogenic Tuber in Tuberous Sclerosis Complex. CNS neuroscience & therapeutics 52.45 15 Juvenile intraductal papilloma mimicking cystic lymphangioma on ultrasonography in a child: a case report. International journal of surgery case reports 47.5 16 Primary osteosarcoma of the scapula in an adolescent: a case report and review of the literature. International journal of surgery case reports 57.0 17 Aggressive mucinous jejunal adenocarcinoma in the setting of chronic immune-mediated disease: diagnostic delay in a patient with celiac disease and sarcoidosis: a case report. International journal of surgery case reports 51.4 18 Benign appendiceal intussusception masquerading as caecal carcinoma intraoperatively in an adolescent male: a case report. International journal of surgery case reports 49.9 19 Could Delayed Primary Epstein-Barr Virus Infection Contribute to the Rising Incidence of Type 1 Diabetes? Reviews in medical virology 56.0 20 Healthcare-Seeking Behaviors and Pathways to Pediatric Oncology Care Among Families of Children with Cancer in a Public Tertiary Hospital in Southeastern Democratic Republic of the Congo: An Observational Study. Cancer management and research 63.4 21 Clinical Outcomes, Implant Survival, and Complications of Expandable Endoprostheses for Lower Limb Reconstruction in Skeletally Immature Patients with Bone Sarcoma: A Systematic Review and Single-Cohort Meta-Analysis. Annals of surgical oncology 78.62 22 Outcomes of haploidentical stem cell transplantation in pediatric Philadelphia chromosome-like B-cell acute lymphoblastic leukemia in the era of immunotherapy. Leukemia & lymphoma 65.42 23 Surgical Management of Fibrolamellar Hepatocellular Carcinoma in Children Versus Adults. Journal of surgical oncology 64.6 24 Classification of patients with early cardiac dysfunction among childhood cancer survivors using a machine learning algorithm with whole heart cycle strain data. Heart and vessels 61.1 25 Challenges in measuring serum calprotectin in autoinflammation: a comparative study of different immunoassays. Molecular and cellular pediatrics 59.5 26 Sacubitril/valsartan for radiation-induced heart disease in children: preclinical and clinical findings. European heart journal 65.3 27 Toxicity and effectiveness of low-dose and conventional-dose co-trimoxazole for treatment of Pneumocystis jirovecii pneumonia in Christchurch, New Zealand: a retrospective cohort study. Infectious diseases (London, England) 75.08 28 Implementation of a student pharmacist-led medication review program prior to metaiodobenzylguanidine (MIBG) imaging in pediatric oncology patients. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 64.9 29 Age-specific Epstein-Barr virus seroprevalence in Costa Rica. PloS one 64.6 30 Specialist Palliative Care in Young Adults With Cancer: A 10-Year Retrospective Cohort Study. The American journal of hospice & palliative care 63.0 31 International Cross-Age Consensus Guideline on Measurable Residual Disease Assessment in Acute Lymphoblastic Leukemia. Blood 71.0 32 Racial and Ethnic Differences in the Incidence of Langerhans Cell Histiocytosis Across the Age Spectrum. Blood advances 57.5
PATIENT-FRIENDLY SUMMARY

Targeting histone deacetylase 1 (HDAC1) in the bone marrow stromal cells revers imatinib resistance by modulating IL-6 in Ph + acute lymphoblastic leukemia.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic