A grade PMID 42321916
View analysis →Finding therapies hidden in 39,079 pediatric cancer papers.
Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
Ranked Discovery Journal Articles
A grade PMID 42690647
View analysis →A grade PMID 42372741
View analysis →A grade PMID 42216567
View analysis →A grade PMID 41916649
View analysis →A grade PMID 42382416
View analysis →A grade PMID 42150584
View analysis →B grade PMID 42748428
View analysis →A grade PMID 41756844
View analysis →A grade PMID 42765973
View analysis →A grade PMID 42362103
View analysis →A grade PMID 42101908
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All ranked pediatric cancer papers
In serum from 12 children with brain tumors and 10 healthy children, fused LIBS and Raman spectral features classified tumor status with a mean accuracy of 92.29% across repeated participant-level train/test splits.
The reported evidence supports preliminary feasibility for serum-based tumor identification; it may, by inference, become a minimally invasive adjunct for diagnosis or monitoring that could inform treatment decisions, but no treatment-selection, outcome, or longitudinal-monitoring benefit was tested.
This paper presents a protocol for a scoping review of cervical cancer screening knowledge, participation barriers, and technological interventions intended to improve awareness and screening uptake, including among adolescents and underserved women.
The record provides no outcome evidence; it proposes investigating whether interventions such as mHealth, SMS reminders, telemedicine, callback systems, and mass media could improve cervical cancer screening awareness and uptake, which might indirectly support earlier detection rather than treat established cancer.
In 4,755 adult survivors of childhood cancer, longitudinal prognostic models identified education, physical activity, income, mental health, and absence of chronic conditions as predictors of optimal or improved physical and mental health-related quality of life.
The observational evidence supports these factors as prognostic correlates; it suggests—but does not demonstrate—that interventions addressing physical activity, mental health, chronic-condition management, or socioeconomic barriers could improve survivor quality of life.
This review synthesizes how glycosylation, phosphorylation, and ubiquitination may regulate copper-transporter activity, trafficking, and stability, and proposes that copper-sensitive post-translational machinery contributes to cellular copper sensing and homeostasis.
The supplied record supports PTM-dependent regulation of copper transporters as a biologically plausible homeostatic framework; by inference, manipulating selected PTM–transporter interactions might eventually enable treatment or biomarker strategies for copper-related disorders or cancers, but no pediatric-oncology model, intervention, or clinical outcome is reported.
Using Polish registry data from 2000–2022 and reimbursement data, the study reports age- and subtype-specific changes in haematolymphoid tumour burden among AYAs, projected growth in selected lymphoma case counts, and marked regional disparities in access to reimbursed drug programmes.
The evidence identifies geographic and organizational gaps in treatment access rather than testing a therapy; it is reasonable but inferential to hypothesize that integrating AYA haemato-oncology into national planning and reducing regional programme disparities could improve timely access and outcomes.
This case report describes complete transoral excision of a benign facial nerve schwannoma in the accessory parotid region of a child, with preserved facial nerve and duct function, no cutaneous scar, and no recurrence reported over 3 years.
The reported case provides preliminary human evidence that a transoral approach can remove a carefully selected pediatric mid-cheek schwannoma while preserving function and appearance; it is only an inference—not established comparative evidence—that this approach may reduce morbidity relative to external surgery in similar patients.
In 102 pediatric patients with cancer, the study found oral Candida in 39 patients, identified candidiasis in 9, described species distribution and medication-associated risk factors, and reported strong in vitro activity for amphotericin B and caspofungin alongside 28.6% fluconazole resistance among C. albicans isolates.
The evidence shows heterogeneous Candida species and isolate-level susceptibility patterns in this population; it is reasonable—but not tested here—to hypothesize that local surveillance and species- or susceptibility-guided antifungal selection could improve stewardship and reduce ineffective empiric therapy.
This report describes a 3-year-old boy with nonmetastatic high-grade bladder urothelial carcinoma who remained disease-free for 18 years after complete transurethral resection followed by surveillance without intravesical therapy.
The case provides evidence that durable disease control after complete resection alone is possible in at least one child; it supports the hypothesis, but does not establish, that carefully selected pediatric patients might avoid intravesical therapy and its associated burden through resection plus intensive surveillance.
This case report describes a 5.5-year-old boy with aggressive DICER1-mutant primary intracranial sarcoma harboring concurrent TP53, PDGFRA, and KEAP1 mutations plus somatic SMARCB1 allelic loss, with progression and new metastatic lesions after subtotal resection and adjuvant chemoradiotherapy.
The record supports molecular profiling as an aid to definitive diagnosis; it is only a hypothesis that the concurrent PDGFRA, KEAP1, TP53, or SMARCB1 alterations could inform targeted treatment selection or resistance research, because no functional testing or genotype-directed therapeutic response is reported.
In a cross-sectional analysis of 157 married Japanese parents with cancer from an online support network, greater parenting concerns were associated with uterine/ovarian cancer, chemotherapy, self-reported psychiatric history, and wanting practical parenting support, without establishing causality or clinical targeting value.
The evidence identifies correlates of parenting concerns but tests no intervention; as an inference requiring prospective confirmation, screening for parenting concerns and offering practical or psychosocial support might improve family-centered supportive care for parents with cancer who are raising minor children.
In a single-center observational cohort of 248 young women with breast cancer in a publicly funded system, fertility preservation participation declined most between initial fertility discussion and specialist consultation, while uptake after consultation was relatively high.
Evidence: documented fertility discussion, specialist consultation, and preservation occurred in 77.8%, 40.7%, and 27.4% of women, respectively. Inference: interventions that improve progression from oncology counseling to fertility-specialist consultation could increase fertility preservation and reduce treatment-related reproductive harm, but this study does not test such an intervention or report fertility outcomes.
In interviews with 30 adult women receiving curative-intent breast cancer treatment at one underserved-community medical center, delayed treatment initiation was associated with reported financial, transportation, and childcare barriers, while patients also described social support and differing preferences about treatment timing.
The study provides qualitative evidence that financial and logistical barriers affect treatment initiation; it is reasonable—but not tested here—to hypothesize that patient navigation, transportation or childcare assistance, financial support, and improved timeline communication could reduce unwanted delays and potentially improve outcomes.