Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
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View analysis →In this single-center retrospective cohort, post-treatment 131I whole-body scintigraphy changed management in only six of 298 patients (2%) receiving adjuvant radioactive iodine without known metastatic disease, while no intermediate-risk patient had iodine-avid foci beyond residual neck uptake.
The evidence shows limited management impact from routine post-treatment scintigraphy in this predominantly non-pediatric cohort; it may therefore support testing a risk-adapted strategy that omits or restricts scanning to reduce unnecessary procedures and burden, but safety, outcome effects, and applicability to children remain unproven.
This case report describes a 15-year-old girl with a longstanding, hypervascular oropharyngeal lesion causing partial airway obstruction whose respiratory symptoms resolved with apparent clinical improvement after six months of oral propranolol.
The reported observation supports only that propranolol coincided with symptomatic and apparent clinical improvement in this patient; it suggests, but does not establish, that propranolol could be a nonsurgical treatment for selected obstructive oropharyngeal hemangiomas in adolescents.
This scoping review identified only three eligible publications on HPV vaccination among American Indian college students aged 18–26 and reported low HPV knowledge, limited perceived risk, gender-related attitude differences, stigma, access barriers, and healthcare mistrust, with no Alaska Native participants represented.
The review supports an evidence-based prevention gap in an underserved population; it is reasonable, but not tested here, to hypothesize that community-engaged, culturally appropriate catch-up vaccination strategies addressing knowledge, access, stigma, and mistrust could increase HPV vaccine uptake and ultimately reduce HPV-associated cancer risk.
This systematic review of 36 reports describing 54 pediatric patients found that atrophic papulosis was usually classified as malignant, commonly involved the CNS and gastrointestinal tract, and often developed systemic manifestations within one year after cutaneous onset.
The review provides evidence supporting early recognition and longitudinal surveillance of pediatric atrophic papulosis; it is reasonable to hypothesize that risk-adapted monitoring could enable earlier management of systemic disease, but the record does not show that any treatment or surveillance strategy improves outcomes.
This single-institution retrospective study of 318 soft tissue sarcoma patients reports a 30.8% wound-healing complication rate, identifies clinical and treatment-associated risk factors, and observes a grade-stratified association between chemotherapy and fewer complications.
Evidence: wound-healing complications were associated with several disease and surgical variables, while chemotherapy appeared protective after stratification by tumor grade. Inference: validated risk models might support perioperative treatment planning, but the record does not establish that chemotherapy prevents wound complications or should be used for that purpose.
This report describes three Ghanaian women with CML who stopped imatinib after pregnancy confirmation, underwent monthly blood-count monitoring, and, among the two retained in follow-up, delivered without reported adverse events or fetal abnormalities and restarted imatinib within six months.
The cases provide limited evidence that coordinated TKI interruption, pragmatic monitoring, and postpartum treatment resumption can be feasible for selected pregnant patients with CML in a resource-limited setting; it remains an inference, not an established safety finding, that the proposed framework improves maternal or fetal outcomes.
In a retrospective cohort of 484 Thai patients with hepatocellular carcinoma, the internally validated eight-variable SPR-HCC score stratified patients into three groups with substantially different overall survival.
The study provides evidence for prognostic risk stratification, not for a treatment effect; it may be hypothesized that the score could support treatment-intensity or supportive-care decisions in resource-limited settings, but this requires external validation and prospective impact testing.
In a hospital-based cross-sectional study of 284 women undergoing breast-cancer care in Vietnam, QLQ-BR45 assessments identified poor sexual functioning, hair-loss distress, systemic-therapy side effects, and demographic, disease, and treatment factors associated with quality-of-life domains.
The study provides observational evidence of specific quality-of-life burdens; it supports the inference that routine screening and targeted sexual-health, psychosocial, and symptom-support interventions could improve supportive care, but it does not test whether such interventions are effective or establish causal effects of treatment type.
In an All of Us survey-based cohort of 18,879 cancer survivors, self-reported inability to obtain needed mental health counseling because of cost was independently associated with higher odds of exceeding moderate drinking and binge drinking.
The evidence establishes an observational association, not treatment efficacy; it suggests the testable hypothesis that improving access to affordable mental health screening and counseling could reduce risky alcohol use among cancer survivors, including potentially adolescent and young-adult survivors.
This exploratory translational study reports that propranolol reduced NLRP3- and pyrin-associated IL-1β responses in murine and human myeloid cells, including monocytes from six patients with familial Mediterranean fever, and reduced plaque formation in a murine atherosclerosis model.
The record provides ex vivo and murine evidence that propranolol suppresses inflammasome-associated inflammatory activity; it may therefore merit investigation as a repurposed anti-inflammatory therapy, but any relevance to pediatric cancer, cancer-associated inflammation, treatment toxicity, or clinical outcomes is currently inferential and untested.
In a cross-sectional online survey of 334 Polish adults aged 18–45 years, self-reported HPV vaccination was substantially less common than favorable attitudes and was associated with vaccine trust, knowing a vaccinated person, female sex, and younger age, while absent clinician recommendation and cost were frequent reported barriers.
The evidence identifies correlates and barriers rather than testing an intervention; it supports the hypothesis that clinician recommendation, reduced financial and access barriers, gender-neutral communication, and social normalization could increase catch-up HPV vaccination and thereby potentially strengthen cancer prevention, but causal effects and pediatric-oncology benefits remain unproven.
In a single-center retrospective pilot cohort of 40 children with intramedullary spinal tumors, T2-weighted MRI radiomics with nested leave-one-out validation differentiated ependymomas from other tumors with moderate-to-good performance but did not adequately differentiate pilocytic astrocytomas.
Evidence: the random forest/LASSO model identified ependymomas with balanced accuracy 0.834, AUC 0.838, sensitivity 0.909, and NPV 0.957 in this retrospective cohort. Inference: if externally validated and shown to add value beyond conventional MRI, such a model could support preoperative diagnostic stratification and treatment planning, but the record provides no evidence of improved therapy selection or patient outcomes.
