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Active intelligence prompt Pediatric cancer: surface high-value therapeutic signals across pediatric oncology literature.
PEDIATRIC CANCER RESEARCH INTELLIGENCE

Finding therapies hidden in 39,040 pediatric cancer papers.

Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.

39,040 Papers indexed
1,440 Papers AI scored
39,040 Ranked papers
100.0% Coverage
PATIENT-FRIENDLY SUMMARY

CHIP-AML22: a complex clinical trial in de novo pediatric AML patients, including a gemtuzumab ozogamicin randomization and targeted therapy with quizartinib in eligible subgroups, within the NOPHO-DB-SHIP consortium.

For education only—not personal medical advice.

LIVE PEDIATRIC ONCOLOGY INTELLIGENCE
↑ Therapeutic signals emerging ↑ New pediatric cancer papers ingested ↑ Cross-paper convergence detected ↑ Human relevance scores updating ↑ Overlooked treatment paths surfacing
TOP PEDIATRIC CANCER SIGNALS

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LATEST PEDIATRIC CANCER PAPERS

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Last ingest 2026-10-08 09:15 AM
1 Direct-Acting Antiviral Therapy in Patients With Hepatocellular Carcinoma Receiving Non-Curative Treatment: High Sustained Virological Response Rates and Preservation of Liver Functional Reserve. Journal of viral hepatitis 47.60 Oct 08, 2026 2 Long-term thyroid outcomes and thiol-disulfide homeostasis in childhood Hodgkin lymphoma survivors treated with neck radiotherapy. Journal of pediatric endocrinology & metabolism : JPEM — Oct 08, 2026 3 The molecular makeup of differentiated thyroid carcinoma in a free-standing children's hospital with a predominantly Hispanic population. Journal of pediatric endocrinology & metabolism : JPEM — Oct 08, 2026 4 Clinical outcomes of psychosocial interventions for healthy siblings of children with cancer: A systematic review and meta-analysis. Journal of pediatric nursing — Oct 08, 2026 5 Imaging-guided shortened interpregnancy interval following myomectomy in China: protocol for a multicentre prospective randomised controlled trial. BMJ open — Oct 08, 2026 6 Quadrivalent human papillomavirus vaccination before pregnancy and pregnancy outcomes: nationwide, population based case-control study. BMJ (Clinical research ed.) — Oct 08, 2026 7 Shapley effects to identify the most influential input parameters of organ dose estimation following CT scans in childhood. Journal of radiological protection : official journal of the Society for Radiological Protection — Oct 08, 2026 8 Global, G20, and China burden of malignant neoplasms of bone and articular cartilage from 1990 to 2050: trends, projections, and ecological associations with healthcare expenditure. Cancer treatment and research communications — Oct 08, 2026
PEDIATRIC CANCER RESEARCH TERMINAL

All ranked pediatric cancer papers

39040 results
C
Role of Respiratory Viral Infections in Airflow Obstruction After Hematopoietic Cell Transplantation.
PMID 42790878 Published: 2026-09-01 Ingested: 2026-09-27 09:15 AM Pediatric transplantation
AI 38.20
Standard 68.0
Final 54.59
AI Summary

In a retrospective cohort of 397 pediatric allogeneic hematopoietic cell transplant recipients, respiratory viral infection within 100 days after transplant was not independently associated with subsequent airflow obstruction, whereas a baseline pulmonary-function lower-limit-of-normal measure predicted risk.

Why It Matters

Evidence: early respiratory viral infection was not an independent airflow-obstruction risk factor after covariate adjustment, while baseline spirometric status carried predictive information. Inference: baseline pulmonary-function measures might help target post-transplant respiratory surveillance or preventive studies, but this record does not demonstrate that any intervention reduces airflow obstruction.

C
Ascaris Lumbricoides through an Intercostal Chest Tube in A Case with Hodgkin's Lymphoma.
PMID 42609696 Published: 2026-08-10 Ingested: 2026-08-20 09:15 AM European journal of case reports in internal medicine
AI 41.20
Standard 65.5
Final 54.57
AI Summary

This report describes a 15-year-old with Hodgkin lymphoma receiving COPDAC chemotherapy whose refractory pleural effusion yielded a live Ascaris lumbricoides through a chest tube, followed by clinical and radiological resolution after albendazole.

Why It Matters

The case provides anecdotal evidence that albendazole was associated with resolution after direct identification of pleural Ascaris; it supports the inference that considering and treating helminthic infection may benefit selected immunocompromised pediatric oncology patients with refractory pulmonary disease, but it does not establish causality, efficacy, or a screening strategy.

B
AI 31.40
Standard 73.5
Final 54.56
AI Summary

This qualitative systematic review synthesized six studies involving 49 pooled participants and identified themes of uncertainty, challenges, resilience, and supportive networks among families of children receiving in-hospital long-term mechanical circulatory support as a bridge to heart transplantation.

Why It Matters

The review supports the need for tailored education, early multidisciplinary involvement, technology-assisted communication, and organized support networks; it is reasonable to infer that such interventions might reduce family uncertainty and distress, but the supplied record reports no intervention testing or demonstrated clinical benefit, including for pediatric oncology families.

C
AI 48.50
Standard 59.5
Final 54.55
AI Summary

In a prospective pilot study of 21 critically ill children with invasive ICP monitoring, cerebral NIRS oxygenation was inversely associated with ICP, while agitation, mean arterial pressure, CRP, and etiology were also associated with ICP burden.

Why It Matters

The study provides associative evidence that cerebral NIRS may complement invasive ICP monitoring and that agitation tracks with higher ICP; it remains an untested inference that NIRS-guided care or distress-reduction interventions would reduce intracranial hypertension or improve outcomes, including in children with intracranial tumors or leukemia.

B
Urinary Biomarkers in Childhood Cancer Survivors with Lower Urinary Tract Dysfunction.
PMID 42575366 Published: 2026-08-10 Ingested: 2026-08-17 12:23 AM Urology
AI 32.90
Standard 72.25
Final 54.54
AI Summary

In a prospective cohort of childhood cancer survivors, urinary ATP, NGF, proNGF, and BDNF showed poor discrimination for lower urinary tract dysfunction, while prior pelvic radiation was associated with increased odds of abnormal uroflow.

Why It Matters

Evidence: the tested urinary biomarkers did not reliably detect therapy-related lower urinary tract dysfunction, although pelvic EBRT identified a higher-risk survivor group. Inference: alternative objective biomarkers or screening strategies focused on pelvic-irradiated survivors could enable earlier detection and management, but no effective test or treatment is established here.

C
Kidney transplantation outcomes in children with WT1-associated kidney disease: a single-center cohort study.
PMID 42568457 Published: 2026-07-24 Ingested: 2026-08-17 12:23 AM Frontiers in pediatrics
AI 51.50
Standard 57.0
Final 54.53
AI Summary

In a retrospective single-center cohort of 13 children with WT1-associated kidney disease, all kidney grafts remained functional after a median 32-month follow-up, with no disease recurrence but frequent Epstein–Barr virus viremia and two cases of post-transplant lymphoproliferative disorder.

Why It Matters

The cohort provides preliminary clinical evidence that kidney transplantation can achieve favorable short- to mid-term graft outcomes in children with WT1-associated disease; it further suggests—but does not establish—that WT1-informed multidisciplinary tumor, gonadal, and Epstein–Barr virus surveillance could improve post-transplant risk management.

C
Multi-Center Evaluation of Opioid Administration or Prescription in Pediatric Oncology Patients Using the OMOP CDM.
PMID 42806519 Published: 2026-10-01 Ingested: 2026-10-01 09:15 AM Cancer medicine
AI 38.70
Standard 67.4
Final 54.49
AI Summary

This three-center retrospective OMOP CDM study found that 93.2% of 2,903 pediatric oncology patients initiating chemotherapy received or were prescribed an opioid, with substantial between-center variation in opioid selection and naloxone use.

Why It Matters

The evidence establishes heterogeneous opioid and naloxone practice patterns but does not test an intervention; it is reasonable to hypothesize that further outcome-linked analyses could identify prescribing or monitoring strategies that improve cancer-pain management or reduce opioid-related harm.

C
Pitfalls in Pediatric Supratentorial ZFTA Fusion-Positive Ependymoma: A Clinicopathological Study of 17 Cases.
PMID 42682089 Published: 2026-09-02 Ingested: 2026-09-04 09:15 AM Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
AI 52.60
Standard 56.0
Final 54.47
AI Summary

In 17 pediatric supratentorial ZFTA fusion-positive ependymomas, the study found frequent non-classical morphology, false-negative fusion testing—particularly with FISH—and diagnostic value from extensive sampling, integrated immunohistochemistry, and complementary molecular platforms.

Why It Matters

The evidence supports improved diagnostic classification rather than a treatment effect; by reducing missed or incorrect ZFTA fusion-positive diagnoses, multimodal testing could indirectly improve risk assessment and treatment selection, but this clinical benefit remains an inference requiring prospective validation.

C
The Proteome of Bone Marrow Multipotent Mesenchymal Stromal Cells Undergoes Significant Alterations in Acute Leukemia Patients at the Onset and During Treatment.
PMID 42653405 Published: 2026-08-19 Ingested: 2026-08-29 09:15 AM International journal of molecular sciences
AI 45.40
Standard 61.84
Final 54.44
AI Summary

In a small human observational study, bone-marrow mesenchymal stromal cells from patients with acute leukemia showed extracellular-matrix, mitochondrial, and vesicular-transport proteomic alterations at diagnosis and remission, whereas donor–patient differences were not detected around allo-HSCT.

Why It Matters

The evidence identifies leukemia-associated stromal proteomic changes but does not test therapy; inferentially, persistent extracellular-matrix or mitochondrial dysfunction in the marrow niche could provide targets for restoring stromal support or modifying treatment response, subject to functional and clinical validation.

C
Phase II Study of Allogeneic Hematopoietic Stem Cell Transplantation for Children and Young Adults with Ewing Sarcoma.
PMID 42580664 Published: 2026-08-11 Ingested: 2026-08-17 12:23 AM Transplantation and cellular therapy
AI 46.40
Standard 61.0
Final 54.43
AI Summary

The record identifies a phase II study of allogeneic hematopoietic stem cell transplantation in children and young adults with Ewing sarcoma, but supplies no efficacy, safety, or enrollment results.

Why It Matters

The title and keywords establish that allogeneic transplantation was clinically studied in Ewing sarcoma; it can only be inferred—not concluded from this record—that donor-mediated graft-versus-tumor activity might improve disease control in relapsed or refractory patients.

B
Hair Dyes in Pregnancy: A Systematic Review and Meta-Analysis.
PMID 42681959 Published: 2026-01-01 Ingested: 2026-09-04 09:15 AM Journal of pregnancy
AI 31.70
Standard 73.0
Final 54.42
AI Summary

This systematic review of 20 observational studies reports low- or very-low-certainty associations between periconceptional or pregnancy hair-dye exposure and several adverse outcomes, including childhood neuroblastoma and Wilms tumor, while finding no association with childhood brain tumors.

Why It Matters

Evidence: pooled observational data associate prenatal hair-dye exposure with neuroblastoma and Wilms tumor but do not establish causality; inference: if specific causal chemicals are identified and the associations are prospectively confirmed, reducing maternal exposure could become a pediatric cancer-prevention strategy rather than a cancer treatment.

C
Approaches to Thyroid Nodules in Paediatric Cancer Predisposition Syndromes.
PMID 42664314 Published: 2026-08-28 Ingested: 2026-08-30 09:15 AM European thyroid journal
AI 50.00
Standard 58.0
Final 54.40
AI Summary

This review synthesizes guidance and observational, pathological, and molecular evidence on evaluating thyroid nodules in children with cancer predisposition syndromes and proposes a syndrome-adapted multidisciplinary risk-assessment framework.

Why It Matters

The supplied evidence supports context-specific integration of ultrasound, cytology, biochemical assessment, and selected molecular testing; it is reasonable but unproven to hypothesize that this approach could improve intervention selection and reduce unnecessary procedures or delayed cancer diagnosis compared with applying adult sporadic-nodule algorithms.

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AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

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