A grade PMID 42321916
View analysis →Finding therapies hidden in 39,040 pediatric cancer papers.
Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
Ranked Discovery Journal Articles
A grade PMID 42690647
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All ranked pediatric cancer papers
In a retrospective cohort of 397 pediatric allogeneic hematopoietic cell transplant recipients, respiratory viral infection within 100 days after transplant was not independently associated with subsequent airflow obstruction, whereas a baseline pulmonary-function lower-limit-of-normal measure predicted risk.
Evidence: early respiratory viral infection was not an independent airflow-obstruction risk factor after covariate adjustment, while baseline spirometric status carried predictive information. Inference: baseline pulmonary-function measures might help target post-transplant respiratory surveillance or preventive studies, but this record does not demonstrate that any intervention reduces airflow obstruction.
This report describes a 15-year-old with Hodgkin lymphoma receiving COPDAC chemotherapy whose refractory pleural effusion yielded a live Ascaris lumbricoides through a chest tube, followed by clinical and radiological resolution after albendazole.
The case provides anecdotal evidence that albendazole was associated with resolution after direct identification of pleural Ascaris; it supports the inference that considering and treating helminthic infection may benefit selected immunocompromised pediatric oncology patients with refractory pulmonary disease, but it does not establish causality, efficacy, or a screening strategy.
This qualitative systematic review synthesized six studies involving 49 pooled participants and identified themes of uncertainty, challenges, resilience, and supportive networks among families of children receiving in-hospital long-term mechanical circulatory support as a bridge to heart transplantation.
The review supports the need for tailored education, early multidisciplinary involvement, technology-assisted communication, and organized support networks; it is reasonable to infer that such interventions might reduce family uncertainty and distress, but the supplied record reports no intervention testing or demonstrated clinical benefit, including for pediatric oncology families.
In a prospective pilot study of 21 critically ill children with invasive ICP monitoring, cerebral NIRS oxygenation was inversely associated with ICP, while agitation, mean arterial pressure, CRP, and etiology were also associated with ICP burden.
The study provides associative evidence that cerebral NIRS may complement invasive ICP monitoring and that agitation tracks with higher ICP; it remains an untested inference that NIRS-guided care or distress-reduction interventions would reduce intracranial hypertension or improve outcomes, including in children with intracranial tumors or leukemia.
In a prospective cohort of childhood cancer survivors, urinary ATP, NGF, proNGF, and BDNF showed poor discrimination for lower urinary tract dysfunction, while prior pelvic radiation was associated with increased odds of abnormal uroflow.
Evidence: the tested urinary biomarkers did not reliably detect therapy-related lower urinary tract dysfunction, although pelvic EBRT identified a higher-risk survivor group. Inference: alternative objective biomarkers or screening strategies focused on pelvic-irradiated survivors could enable earlier detection and management, but no effective test or treatment is established here.
In a retrospective single-center cohort of 13 children with WT1-associated kidney disease, all kidney grafts remained functional after a median 32-month follow-up, with no disease recurrence but frequent Epstein–Barr virus viremia and two cases of post-transplant lymphoproliferative disorder.
The cohort provides preliminary clinical evidence that kidney transplantation can achieve favorable short- to mid-term graft outcomes in children with WT1-associated disease; it further suggests—but does not establish—that WT1-informed multidisciplinary tumor, gonadal, and Epstein–Barr virus surveillance could improve post-transplant risk management.
This three-center retrospective OMOP CDM study found that 93.2% of 2,903 pediatric oncology patients initiating chemotherapy received or were prescribed an opioid, with substantial between-center variation in opioid selection and naloxone use.
The evidence establishes heterogeneous opioid and naloxone practice patterns but does not test an intervention; it is reasonable to hypothesize that further outcome-linked analyses could identify prescribing or monitoring strategies that improve cancer-pain management or reduce opioid-related harm.
In 17 pediatric supratentorial ZFTA fusion-positive ependymomas, the study found frequent non-classical morphology, false-negative fusion testing—particularly with FISH—and diagnostic value from extensive sampling, integrated immunohistochemistry, and complementary molecular platforms.
The evidence supports improved diagnostic classification rather than a treatment effect; by reducing missed or incorrect ZFTA fusion-positive diagnoses, multimodal testing could indirectly improve risk assessment and treatment selection, but this clinical benefit remains an inference requiring prospective validation.
In a small human observational study, bone-marrow mesenchymal stromal cells from patients with acute leukemia showed extracellular-matrix, mitochondrial, and vesicular-transport proteomic alterations at diagnosis and remission, whereas donor–patient differences were not detected around allo-HSCT.
The evidence identifies leukemia-associated stromal proteomic changes but does not test therapy; inferentially, persistent extracellular-matrix or mitochondrial dysfunction in the marrow niche could provide targets for restoring stromal support or modifying treatment response, subject to functional and clinical validation.
The record identifies a phase II study of allogeneic hematopoietic stem cell transplantation in children and young adults with Ewing sarcoma, but supplies no efficacy, safety, or enrollment results.
The title and keywords establish that allogeneic transplantation was clinically studied in Ewing sarcoma; it can only be inferred—not concluded from this record—that donor-mediated graft-versus-tumor activity might improve disease control in relapsed or refractory patients.
This systematic review of 20 observational studies reports low- or very-low-certainty associations between periconceptional or pregnancy hair-dye exposure and several adverse outcomes, including childhood neuroblastoma and Wilms tumor, while finding no association with childhood brain tumors.
Evidence: pooled observational data associate prenatal hair-dye exposure with neuroblastoma and Wilms tumor but do not establish causality; inference: if specific causal chemicals are identified and the associations are prospectively confirmed, reducing maternal exposure could become a pediatric cancer-prevention strategy rather than a cancer treatment.
This review synthesizes guidance and observational, pathological, and molecular evidence on evaluating thyroid nodules in children with cancer predisposition syndromes and proposes a syndrome-adapted multidisciplinary risk-assessment framework.
The supplied evidence supports context-specific integration of ultrasound, cytology, biochemical assessment, and selected molecular testing; it is reasonable but unproven to hypothesize that this approach could improve intervention selection and reduce unnecessary procedures or delayed cancer diagnosis compared with applying adult sporadic-nodule algorithms.