A grade PMID 42321916
View analysis →Finding therapies hidden in 39,079 pediatric cancer papers.
Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
Ranked Discovery Journal Articles
A grade PMID 42690647
View analysis →A grade PMID 42372741
View analysis →A grade PMID 42216567
View analysis →A grade PMID 41916649
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View analysis →A grade PMID 42150584
View analysis →B grade PMID 42748428
View analysis →A grade PMID 41756844
View analysis →A grade PMID 42765973
View analysis →A grade PMID 42362103
View analysis →A grade PMID 42101908
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All ranked pediatric cancer papers
This case report describes an antenatally detected, persistent abdominal cyst in a term female neonate that was non-specific on imaging, found surgically to arise from the right adnexa, and diagnosed histopathologically as ovarian serous cystadenoma.
The reported evidence shows that a rare benign ovarian neoplasm can mimic other neonatal abdominal cysts and be identified through surgical exploration and histopathology; it is reasonable but unproven to infer that including serous cystadenoma in the differential diagnosis could improve operative planning and selection of persistent or large lesions for timely intervention.
This cross-sectional study of 99 healthy Brazilian adults establishes age-stratified reference values for the Brazilian Portuguese TOMASS and reports moderate-to-excellent test-retest and good-to-excellent inter-rater reliability.
The evidence supports TOMASS as a reliable, low-cost swallowing assessment in healthy Brazilian adults; it could hypothetically help monitor treatment-related mastication or swallowing dysfunction, but the record provides no evidence in children, patients with cancer, or therapeutic-intervention settings.
This retrospective cohort of 32 eyes from 30 patients with uveitis reported improved visual acuity after pars plana vitrectomy, 93.8% final anatomical success among retinal-detachment cases, and no severe postoperative inflammation.
The record supports PPV as a surgical and diagnostic approach for selected uveitis complications; any pediatric-oncology value—such as facilitating diagnosis of suspected vitreoretinal lymphoma—is inferential because no pediatric subgroup, cancer-specific diagnostic yield, or oncologic outcome is reported.
This single-patient report describes Hirschsprung’s disease diagnosed in a 61-year-old with a synchronous rectosigmoid neoplasm, managed by combined abdominal–transanal resection, lymphadenectomy, coloanal anastomosis, protective ileostomy, and adjuvant chemotherapy, with no residual disease reported on post-treatment CT.
The case provides evidence that multidisciplinary adult and pediatric colorectal expertise can facilitate definitive management of unusually late-presenting Hirschsprung’s disease with synchronous colorectal carcinoma; any hypothesis that chronic intestinal stasis promotes malignancy, or that this operative strategy improves outcomes over alternatives, remains untested inference.
Across multiple genomic datasets and correlation methods, the study reports no significant genome-wide genetic correlation and only three locally pleiotropic loci between estrogen receptor-positive breast cancer risk and reproductive life-history traits in European populations.
The supplied evidence does not support a therapeutic intervention; at most, it suggests that broad reproductive-trait polygenic architecture is unlikely to provide a strong basis for ER-positive breast cancer treatment selection, while the three reported pleiotropic loci could be explored as hypothesis-generating signals without assuming therapeutic relevance.
In a cross-sectional survey of 6,145 U.S. adults, prior cancer-information seeking was associated with approximately a 5-percentage-point higher adjusted probability of awareness of multi-cancer detection tests.
The study provides evidence of an association between information seeking and MCD-test awareness; it supports only the inference that communication interventions might increase awareness, not that they improve screening uptake, cancer outcomes, or pediatric oncology care.
This retrospective comparative cohort study investigated whether individualized nutritional intervention was associated with inflammatory biomarkers, metabolic parameters, gene polymorphisms, and pregnancy outcomes in women with gestational diabetes, but the supplied abstract reports no results.
The record establishes only that nutrition, glycemic measures, TNF-α, IL-6, adiponectin, and related polymorphisms were assessed in GDM; it may be hypothesized that individualized nutrition improves insulin resistance by shifting inflammatory or adipokine profiles, but no supporting effect estimates or outcomes—and no pediatric-cancer relevance—are provided.
This single-center retrospective study of 133 patients with Klinefelter syndrome found that higher-grade sex chromosome aneuploidies were associated with younger diagnosis and more congenital, dysmorphic, and neurodevelopmental findings than classical 47,XXY, while most diagnoses followed adult infertility evaluation.
The evidence supports karyotype-associated differences that may help prioritize earlier developmental and endocrine assessment; any claim that such screening improves treatment outcomes, reproductive outcomes, or malignancy prevention remains an untested inference.
In a cross-sectional analysis of Brazil's 2019 National Health Survey, non-heterosexual women were less likely than heterosexual women to report a Papanicolaou test within the previous three years.
The evidence identifies an association between sexual orientation and lower recent cervical-screening uptake; it can be inferred—but is not tested here—that targeted, inclusive screening initiatives might reduce this disparity and potentially improve cervical cancer prevention or early detection.
This report describes a 12-year-old girl with prior Wilms tumor who developed orbital embryonal rhabdomyosarcoma and had a likely pathogenic TRIP13 null variant suggesting mosaic variegated aneuploidy syndrome 3.
The case provides evidence that recognizing a possible TRIP13-associated cancer-predisposition syndrome can prompt genetic counseling and systemic surveillance; it is an inference, not demonstrated here, that earlier syndrome identification could improve tumor surveillance or treatment planning.
This retrospective registry study describes 542 retinoblastoma cases diagnosed in Saudi Arabia from 2000–2019, reporting age-standardized incidence trends, regional variation, and tumor classification patterns.
The evidence identifies geographic disparities and baseline incidence patterns but does not test a therapy; it may be inferred that better surveillance, resource allocation, and earlier detection in underserved regions could improve care, although clinical benefit was not evaluated.
This Monte Carlo risk assessment reports modeled moderate non-carcinogenic risk and elevated calculated carcinogenic risk for several contaminants from potato-chip consumption, with children generally showing greater concern than adults.
The record supports a food-safety prevention hypothesis—not a treatment hypothesis—that reducing metals, pesticides, and mycotoxins in potato chips could lower children's dietary exposure and modeled long-term cancer risk; whether such mitigation reduces actual cancer incidence is untested.