A grade PMID 42321916
View analysis →Finding therapies hidden in 39,079 pediatric cancer papers.
Neurocompute scores pediatric oncology literature, surfaces overlooked therapeutic signals, and turns fragmented childhood cancer research into a living discovery terminal.
Ranked Discovery Journal Articles
A grade PMID 42690647
View analysis →A grade PMID 42372741
View analysis →A grade PMID 42216567
View analysis →A grade PMID 41916649
View analysis →A grade PMID 42382416
View analysis →A grade PMID 42150584
View analysis →B grade PMID 42748428
View analysis →A grade PMID 41756844
View analysis →A grade PMID 42765973
View analysis →A grade PMID 42362103
View analysis →A grade PMID 42101908
View analysis →Database feed
All ranked pediatric cancer papers
In a retrospective cohort of 125 patients with primary sacrococcygeal pilonidal sinus disease, phenol therapy was associated with faster wound healing and return to work than Karydakis flap surgery, while 1-year recurrence rates were not significantly different.
The reported evidence supports phenol therapy as a potentially less burdensome treatment for selected patients with primary pilonidal sinus disease; any relevance to pediatric oncology is unsupported because the condition is explicitly non-neoplastic and no cancer population or anticancer mechanism was studied.
In a cross-sectional study of 62 adults with basal cell naevus syndrome, participants reported lower health-related quality of life and more everyday executive deficits than the general population, while anxiety and executive deficits were associated with poorer mental quality of life.
The study provides observational evidence supporting anxiety and executive-function screening in adults with basal cell naevus syndrome; it is reasonable but untested to infer that screening followed by targeted psychological or cognitive support could improve quality of life.
This cross-sectional study of 175 children attending two Mogadishu referral hospitals found 37.1% stool-antigen positivity for H. pylori and associations with rural residence, lower parental education, unwashed produce, and street-food consumption.
The evidence identifies potentially modifiable exposure correlates but does not test an intervention; it may be hypothesized that sanitation, caregiver education, and safer food handling could reduce childhood H. pylori infection and, indirectly, later gastric disease risk, including gastric cancer risk, but this requires prospective interventional confirmation.
Using SEER survival data from 1975-2017, this observational study reports that US adolescents and young adults had slower gains in 5-year relative cancer survival than younger and older patients before 1998 but comparatively faster gains after 2000, with the HIV/AIDS epidemic substantially affecting trends in males.
The evidence identifies historical age- and era-specific survival patterns rather than testing a therapy; inferentially, examining cancer-specific drivers of the remaining AYA survival gaps could help prioritize treatment access, trial enrollment, supportive care, or other interventions, but this record does not establish which actions improved survival.
This case report describes a 1-year-old child receiving chemotherapy for optic glioma who developed large non-traumatic bilateral subdural hematomas and improved clinically and radiologically after urgent surgical evacuation and drain placement.
The reported evidence supports prompt neurosurgical evacuation as effective acute management in this single patient; it only suggests, without establishing, that serial head-circumference monitoring and timely neuroimaging might facilitate earlier detection of this rare complication in children receiving treatment for central nervous system tumors.
This case report describes a 2-month-old infant with a malignant intra-abdominal mixed germ cell tumour initially suspected to be hepatoblastoma who remained disease free at 3 years after resection and adjuvant bleomycin, carboplatin, and etoposide chemotherapy.
The reported outcome provides limited evidence that surgery followed by platinum-based combination chemotherapy can achieve durable disease control in this rare presentation; it is only an inference—not established by this single case—that this approach is broadly effective or optimal for neonatal intra-abdominal mixed germ cell tumours.
This management overview reports that most infantile hemangiomas involute without treatment, while complicated lesions are treated first-line with oral propranolol and surgery is generally reserved for cases unresponsive to medical therapy.
The supplied record presents propranolol as an established treatment for complicated infantile hemangioma; it does not test a new therapeutic hypothesis, although it implies that treatment stratification by complication status and medical response may guide escalation to surgery.
In interviews with 12 school personnel in Türkiye, the study identified academic, health, social, and emotional challenges during school re-entry after childhood cancer, alongside deficits in individualized planning, health information, role clarity, and school–health care coordination.
The study provides qualitative evidence of school-side coordination and support gaps; it is reasonable—but not tested here—to hypothesize that structured interdisciplinary re-entry programs involving pediatric oncology teams, families, and schools could improve educational continuity and psychosocial adjustment.
This case report describes a child with metastatic retroperitoneal embryonal rhabdomyosarcoma, substantial estimated volumetric response to induction chemotherapy, conservative local surgery, and subsequent deterioration and death, emphasizing imaging and biopsy challenges throughout care.
The record supports imaging as useful for diagnosis, staging, response assessment, and follow-up; it only suggests, rather than demonstrates, that improved imaging-guided sampling and surveillance strategies could better inform treatment decisions in heterogeneous retroperitoneal rhabdomyosarcoma.
In neonatal MHV68-infected mice, genetic background, viral inoculum, and sex were associated with differences in systemic latent infection, germinal-center responses, and splenomegaly, with latent virus localized to splenic germinal-center B cells in susceptible animals.
The evidence shows that host genetic background and exposure dose modify neonatal gammaherpesvirus latency and B-cell responses in mice; it can only be inferred—not established—that identifying the responsible host pathways might reveal targets for preventing or limiting chronic infection and subsequent virus-associated malignancy risk.
This case report describes an 11-year-old girl with triquetral osteoid osteoma initially suspected to have septic arthritis on MRI, subsequently identified by high-resolution CT and confirmed histologically after surgical excision relieved her symptoms.
The reported evidence supports CT-guided recognition followed by surgical excision in this individual case; it suggests—but does not establish—that earlier CT imaging in children with persistent nocturnal, salicylate-responsive wrist pain and disproportionate MRI edema could reduce diagnostic delay and unnecessary infection-directed care.
In a retrospective cohort of 41 predominantly older adults with hepatocellular carcinoma, six-month shrinkage of the CT-defined radiofrequency ablation volume was lower with impaired liver function, advanced fibrosis, and certain hepatic lesion locations, with albumin and total bilirubin independently associated with shrinkage rate.
The study provides observational evidence that baseline liver function is associated with post-RFA ablation-volume evolution; it may be inferred—but is not demonstrated—that serial volumetric CT combined with albumin and bilirubin could help interpret treatment response or tailor surveillance after RFA.