Exosomal miR-1278 From Bone Marrow Mesenchymal Stem Cells Modulates Ldha-Mediated Microglia Polarization to Decelerate Parkinson's Disease Pathology.
Bone marrow mesenchymal stem cell-derived exosomes carrying miR-1278 modulate LDHA-dependent microglial polarization and attenuate Parkinson's-like pathology in preclinical models.
What the AI sees
Bone marrow mesenchymal stem cell-derived exosomes carrying miR-1278 modulate LDHA-dependent microglial polarization and attenuate Parkinson's-like pathology in preclinical models.
Research significance
Identifies a mechanistic, targetable axis connecting exosome-delivered miRNA, microglial metabolic/inflammatory state and neuroprotection, supporting development of exosome- or LDHA/miR-1278-focused therapeutic strategies for Parkinson's disease.
Source abstract
No abstract available.