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RESEARCH PAPER ANALYSIS

Virtual reality as a therapeutic tool in modern healthcare.

This review describes virtual reality's growing use across medicine and notes some beneficial but methodologically limited evidence for motor rehabilitation and symptom management in Parkinson's disease.

PMID41920719

JournalCasopis lekaru ceskych

Publication Date2026-01-01

Ingested2026-04-28 08:58 PM

EXECUTIVE SUMMARY

What the AI sees

This review describes virtual reality's growing use across medicine and notes some beneficial but methodologically limited evidence for motor rehabilitation and symptom management in Parkinson's disease.

WHY IT MATTERS

Research significance

VR is valuable for symptomatic rehabilitation, objective outcome measurement, and potential digital biomarkers in PD trials, but it offers minimal actionable molecular or target-based insights for Parkinson's therapeutic discovery.

ABSTRACT

Source abstract

Virtual reality has rapidly established itself in recent years as an innovative component of modern medicine. It is applied in rehabilitation, neurology, oncology, psychotherapy, geriatric care, and many other areas of clinical practice. Advanced systems make it possible to create individualized, controlled, and interactive environments for training motor, cognitive, and behavioral functions, while providing immediate feedback and objective measurement of patient performance. The technology is used not only in therapy, but also in healthcare education, surgical simulation, and crisis-scenario training. Clinical studies and meta-analyses demonstrate beneficial effects of virtual reality on anxiety, depression, motor rehabilitation after stroke, Parkinson's disease, and postural stability in older adults. Despite these promising results, significant limitations remain, including methodological shortcomings of existing studies, technical and organizational barriers, the risk of cybersickness, and the need for protocol standardization. Projects in the Czech Republic illustrate the practical application of virtual reality; however, fully unlocking its potential will require ongoing research and long-term monitoring to objectively evaluate its effectiveness, safety, and sustainability.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine

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B, Biointerfaces 86.0 13 Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases. Experimental physiology 84.0 14 Flavonoid Rutin Reduces Intestinal Inflammation in an Experimental Model of Parkinson's Disease. Neurotoxicity research 70.0 15 Nanostructured Lipid Carriers Enhance Brain Delivery and Antioxidant Efficacy of a Small-Molecule MAO B Inhibitor for Neurodegenerative Disease Therapy. Molecular pharmaceutics 78.0 16 Pathophysiological Role of the Gut Brain Axis in Parkinson's Disease: From Microbial Metabolites and Intestinal Permeability to Central Neuroinflammation. Current neurovascular research 86.0 17 Parkinson's Disease: From Metabolism to Genetics-A Comprehensive Review. Current issues in molecular biology 86.0 18 Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders. Neuroprotection (Chichester, England) 76.0 19 Integrative network pharmacology delineates dual GPCR and non-GPCR mechanisms of blended and individual Taikong Blue lavender and Pingyin rose essential oils in neurodegenerative and psychiatric disorders. Computers in biology and medicine 65.0 20 Models of neuroprotection in Parkinson's disease: Exploring cellular, molecular, and microenvironmental targets. Experimental neurology 78.0 21 Hyaluronic acid: emerging roles and biomaterial innovations in Alzheimer's and Parkinson's disease therapy. Frontiers in pharmacology 75.2 22 Molecular mechanisms underlying Parkinson's disease and role of phytochemicals, α-synuclein, sirtuins, and incretin mimetics in potential therapy. Frontiers in pharmacology 75.0 23 Lipid droplets in neurodegenerative diseases: pathological drivers and therapeutic vulnerabilities. Cell death discovery 82.0 24 Brain-gut-microbiota axis: a review on the bidirectional regulatory mechanisms between gut microbiota and brain and their disease interactions. Frontiers in microbiology 74.0 25 Long non-coding RNAs in neurodegenerative diseases - Molecular mechanisms, liquid biopsy biomarkers, and therapeutic targets: A review. Biomolecules & biomedicine 84.0 26 Neurosyphilis and Parkinsonism: Overlapping Pathophysiology and Emerging Therapeutic Insights. Current neurovascular research 76.0 27 Molecular biochemistry of soluble epoxide hydrolase in lipid mediator pathways and neuroinflammatory responses. The Journal of steroid biochemistry and molecular biology 82.0 28 Multifaceted role of CNPY2 beyond ER stress: Disease implications and therapeutic potential. Cell stress 83.3 29 Neuroprotective Role of Exercise-based Physiotherapy Combined with Pharmacological Agents in Parkinson's Disease. Central nervous system agents in medicinal chemistry 64.0 30 Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder. Signal transduction and targeted therapy 84.0 31 HMGB1-mediated neuroinflammation: molecular mechanisms and emerging therapeutic approaches. Inflammopharmacology 78.0 32 Beyond acid-base dyshomeostasis: Dynamic instability of neuronal lysosomal pH as a pathogenic mechanism and therapeutic target in neurological diseases. Biochemical pharmacology 88.0

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