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RESEARCH PAPER ANALYSIS

Headaches in Parkinson's disease: a comprehensive review.

A narrative review summarizing epidemiology, classification, proposed pathophysiology, and clinical management of headaches in Parkinson's disease, noting prevalence (up to ~49%), types (tension-type, migraine), links to motor fluctuations and dopaminergic therapy, and evidence from cohorts and…

PMID41919457
JournalNeurologia i neurochirurgia polska
Publication Date2026-04-01
Ingested2026-04-28 08:58 PM
EXECUTIVE SUMMARY

What the AI sees

A narrative review summarizing epidemiology, classification, proposed pathophysiology, and clinical management of headaches in Parkinson's disease, noting prevalence (up to ~49%), types (tension-type, migraine), links to motor fluctuations and dopaminergic therapy, and evidence from cohorts and…

WHY IT MATTERS

Research significance

Although it does not advance core molecular targets for disease-modification, the paper highlights an underrecognized non-motor phenotype and mechanistic themes (nociceptive and neuroplastic pain, therapy-related effects) that can inform symptomatic management, patient stratification, and ancillary…

ABSTRACT

Source abstract

Headaches are common but underrecognized non-motor symptoms in Parkinson's disease (PD). They may appear as primary headaches, secondary headaches or as a part of PD-related nociceptive and neuroplastic pain syndromes. The prevalence of headaches in PD varies widely, with observational studies suggesting that up to 49% of patients report headaches, including tension-type headaches (TTH) and migraines. Headaches related to PD may present prodromally, occur during motor fluctuations or as a side effect of dopaminergic therapy. This review summarizes the epidemiology, classification, pathophysiology and clinical management of headaches in PD, with an emphasis on evidence from population-based cohort studies, imaging research, and clinical observations.

SUPPORTING PAPER SET

32 more papers to review

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Central nervous system agents in medicinal chemistry 64.0 30 Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder. Signal transduction and targeted therapy 84.0 31 HMGB1-mediated neuroinflammation: molecular mechanisms and emerging therapeutic approaches. Inflammopharmacology 78.0 32 Beyond acid-base dyshomeostasis: Dynamic instability of neuronal lysosomal pH as a pathogenic mechanism and therapeutic target in neurological diseases. Biochemical pharmacology 88.0
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