This review/meta-analysis reports that citicoline improves cognitive impairment across vascular and neurodegenerative conditions and cites evidence for benefit in mild cognitive impairment in Parkinson's disease with suggested dosing regimens (e.g., 1000 mg/day for 12–18 months).

This entry is a correction notice to a report on potent, selective, CNS-penetrant macrocyclic LRRK2 inhibitors for Parkinson's disease and contains no new experimental abstract or actionable data.

This study finds elevated monocyte LRRK2 kinase activity (pRab10Thr73) in PD patients carrying the Asian-prevalent p.G2385R variant—markedly higher in rare double p.G2385R/p.R1628P carriers—and reduced pLRRK2Ser935 across PD groups, with a subset of idiopathic PD patients also showing increased…

Sequencing of LRRK2 in 20,519 Chinese individuals reveals enrichment of known pathogenic/likely pathogenic variants in PD, identifies novel candidate pathogenic variants (e.g., p.A312V, p.M968K, p.R1320S), and confirms common PD-associated alleles (p.A419V, p.R1628P, p.G2385R) with no similar…

Using resting-state fMRI and a novel Weighted Eigenvector Dynamics Analysis, the study shows that STN-DBS and noninvasive STN-targeted temporal interference stimulation normalize cortical metastable dynamics by restoring occupancy of a metastable substate (a VN–SMN/VAN decoupling) that correlates…

This paper presents a biointegrable soft neural interface enabling stable multi-regional recordings in Parkinson's disease mice and shows that wireless magnetogenetic DBS selectively modulates pathological beta-band oscillations and cortico‑basal ganglia‑thalamic synchrony, with therapeutic effects…

The authors develop an MspA nanopore single-molecule assay that resolves three reproducible current states of monomeric α‑synuclein, maps them to α‑helical and random‑coil subdomains, and generates a biophysical parameter matrix to profile structural heterogeneity of variants.

31P MR spectroscopy detected altered midbrain energy metabolism (lower Pi/PCr, higher ATP/Pi) in early-stage PD versus mimics, correlated with nonmotor/autonomic symptoms, and achieved high diagnostic accuracy (AUC 0.90) outperforming iron and neuromelanin MRI.

Using a viral hTyr rat model to induce neuromelanin, the study shows that NM accumulation alters nigral dopamine neuron survival, intrinsic firing and mitochondrial function with higher NM levels in males and sex-biased motor and non-motor (anxiety) phenotypes.

This study demonstrates that an automated programming algorithm using intraoperatively recorded evoked resonant neural activity (ERNA) produces acute motor improvements equivalent to expert clinician and imaging-guided STN-DBS settings in Parkinson's patients, with ERNA recordings taking under one…

Using intraoperative STN local field potentials and simultaneous cortical ECoG from seven PD patients, the study shows cortico‑STN beta-band coupling is significantly elevated during brief high‑amplitude beta bursts and collapses to surrogate levels outside those bursts.

The paper presents a wireless, minimally invasive magnetomechanical deep brain stimulation using magnetite nanodiscs to remotely modulate subthalamic nucleus activity and restore motor function in hemiparkinsonian mice.

This study presents TuneS, a patient-specific, model-based pipeline to optimize deep brain stimulation contact configurations and targets (including STN motor subdivisions and streamlines) to maximize intended target engagement while minimizing stimulation of avoidance regions.

Using DOPC-cholesterol giant unilamellar vesicles, the paper demonstrates that the N-terminal region of α‑synuclein is required for membrane binding and vesicle clustering, while full-length and C‑terminal truncated forms promote clustering and membrane permeabilization, with monomers causing…

Longitudinal analysis of 1,238 PPMI participants shows CSF alpha-synuclein seed amplification assay results are highly stable over a median 2-year follow-up (~90%+ concordance across PD, prodromal, and control groups) with low rates of conversion between positive and negative.

Phase 1 randomized crossover thorough QTc study in 37 healthy volunteers found BIA 28-6156, an allosteric GCase activator for GBA-associated Parkinson’s, produced no clinically relevant QTc prolongation and was generally well tolerated.

MAFNet is an end-to-end deep‑learning pipeline that integrates temporal denoising, swarm-based feature selection, and graph‑attention multimodal fusion to stage Parkinson's disease from SNPs, neuroimaging, and UPDRS data, reporting 97.6% accuracy on PPMI (n=200) and nominating LRRK2 variants,…

This cross-cohort study found targeted plasma proteomics markedly outperformed whole-blood transcriptomics and multimodal fusion for classifying Parkinson's disease (best proteomic Random Forest AUROC=0.872) and derived a Proteomic Severity Index that explained ~28% of motor severity variance with…

The paper presents a robust bacterial coexpression method to produce authentic Ser129-phosphorylated α-synuclein and demonstrates that true pS129 differs from the S129D phosphomimetic in local structure, aggregation behavior, and modest neuronal toxicity.

Whole-exome sequencing, burden testing, Mendelian randomization, and colocalization in a European cohort identified enrichment of rare variants in multiple DNAJC genes and provide convergent genetic evidence implicating DNAJC13 (and shared signals for DNAJC19) as Parkinson's disease susceptibility…