This study demonstrates that an alpha-synuclein seed amplification assay applied to routine clinical CSF samples reliably detects Lewy body pathology and aligns well with clinical diagnoses of Parkinson's disease and dementia with Lewy bodies.

Wdfy3 haploinsufficiency in mice impairs selective autophagy and produces proteomic and histological signatures that overlap presymptomatic Parkinson's disease, particularly in cortex and substantia nigra.

This study presents a semi-automated 3D volumetric immunofluorescence quantification method for intraneural S129 phospho-α-synuclein in skin biopsies that discriminates synucleinopathies (PD/MSA) from PSP with high AUC, sensitivity and specificity in a small cohort.

Using Mendelian randomization in large European samples, the study implicates specific plasma lipids (e.g., triacylglycerol and phosphatidylcholine as protective; sphingomyelin as pathogenic), two trace elements (selenium protective; an unexpected iridium signal), and CSF metabolites (including…

This review surveys AI/ML approaches for discovering and validating molecular, imaging, and digital biomarkers related to motor dysfunction across PD, HD, ALS, and SCAs—highlighting candidates such as alpha-synuclein, tau, and neurofilament light chain and the promise of multimodal models while…

This study establishes a refined chronic low-dose MPTP/probenecid regimen in mature adult mice that yields progressive motor and cognitive impairments, sustained loss of tyrosine hydroxylase-positive neurons, and phosphorylated α-synuclein aggregation while preserving high survival for longitudinal…

Combines CatWalk gait analysis and DeepLabCut markerless pose estimation in L61 α‑synuclein mice to generate sensitive, complementary motor endpoints (tail‑base lateral variance and hind base of support) that distinguish transgenic from control animals at 12 and 18 months.

The study reports elevated urine 22:6-BMP in PSP that correlates with CSF total LRRK2, shows that a PD-linked LRRK2 variant associates with higher CSF LRRK2, and that baseline monocyte LRRK2 predicts 1‑year clinical decline, supporting LRRK2 and lysosomal biomarkers in PSP.

Combined analysis of skin morphometry (reduced α-syn–positive fibers, increased collagen IV staining and α-syn–positive melanocytes) plus salivary α-syn oligomers discriminates Parkinson's patients from controls and correlates with clinical scores.

The paper shows that circ-find-0001774 sponges miR-153-3p to boost Wnt/β-catenin signaling, lowering autophagy/apoptosis and improving dopaminergic neuron survival and motor behavior in MPP+/MPTP PD models.

Using explainable radiomic features from standard T1/T2 MRI in basal ganglia and ventral midbrain, the study accurately discriminates PD, SWEDD, and healthy controls (macro-AUC 0.85) and highlights ventral midbrain texture heterogeneity and thalamic contrast as top predictors.

Using resting-state fNIRS and graph-theory, the study found that Parkinson's patients with wearing-off exhibit a less efficient cortical network (reduced clustering and global efficiency, increased path length) with nodal abnormalities in premotor and somatosensory cortices, and that global…

Autoradiographic [18F]nifene binding to α4β2* nicotinic acetylcholine receptors is markedly increased in the hippocampus–subiculum of postmortem Parkinson's disease brains compared with controls, with noted sex- and age-related differences.

Introduces Decomposed Transfer Entropy (DTE) to separate phase, spectral amplitude, and interaction contributions to directed EEG connectivity and shows PD patients off medication exhibit a phase-dominant reweighting from frontal midline (Fz) that shifts toward healthy patterns with dopaminergic…

This review synthesizes evidence that neurovascular unit (NVU) and blood–brain barrier (BBB) dysfunction driven by immune mechanisms and disease-specific insults (e.g., α-synuclein in PD) contributes to neuroinflammation and neuronal injury across neurodegenerative diseases.

In 14 PD patients, dopaminergic medication improved temporal precision and coordination of muscle synergies during sit-to-stand, producing earlier seat-off, shorter movement duration, and better coupling of propulsive and postural stabilization synergies.

This review synthesizes mechanistic and preclinical evidence that micronutrients, bioactive lipids, and phytochemicals can modulate glymphatic function—via AQP4 expression/polarization, BBB integrity, reduced neuroinflammation, and improved sleep/cerebrovascular function—with implications for…

The paper reports routine incorporation of AD CSF biomarkers and alpha-synuclein skin biopsy into iNPH evaluations, finding ~32% AD-consistent CSF profiles and ~31% biopsy-confirmed alpha-synuclein pathology among patients.

In 45 Parkinson's patients, greater non-motor symptom burden predicted lower overall levodopa responsiveness, while poorer semantic fluency specifically predicted reduced levodopa responsiveness of axial symptoms.

This in vitro study shows that a protein encoded by circFKBP8(5S,6) (cFKBP8) is upregulated in MPP+-treated SH-SY5Y cells and that cFKBP8 overexpression raises while its silencing lowers α-synuclein levels.